KEGG   Mus musculus (house mouse): 11684
Entry
11684             CDS       T01002                                 
Symbol
Alox12, 9930022G08Rik, Alox12p, P-12LO
Name
(RefSeq) arachidonate 12-lipoxygenase
  KO
K00458  arachidonate 12-lipoxygenase [EC:1.13.11.31]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00590  Arachidonic acid metabolism
mmu01100  Metabolic pathways
mmu01523  Antifolate resistance
mmu04726  Serotonergic synapse
mmu04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    11684 (Alox12)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    11684 (Alox12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    11684 (Alox12)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    11684 (Alox12)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.31  arachidonate 12-lipoxygenase
     11684 (Alox12)
SSDB
Motif
Pfam: Lipoxygenase PLAT
Other DBs
NCBI-GeneID: 11684
NCBI-ProteinID: NP_031466
MGI: 87998
Ensembl: ENSMUSG00000000320
UniProt: P39655 A2CF85
Position
11:complement(70132283..70146206)
AA seq 663 aa
MGRYRVRVVTGAWLFSGSLNLVRLWLVGEHREAKLELQLRPARGKEEEFDFDVPEDLGPL
QFVKLHKQHTVVDDAWFCNLITVQGPGTSAEAVFPCYRWVQGEGILSLPEGTARLAGDNA
LDVFQKYREKELKERQQTYCWATWKEGLPQTIAADCKDDLPPNMRFHEEKRLDFEWTLKA
GVLEMGLKRVYTLLRSWNHLEDFDQIFWGQKSALAEKVHQCWQEDELFGYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELKNGSLFEADFILLDGIPANVIRGEPQYLAAPL
VMLRMDPGGKLLPMAIQIQPPNPSSPAPTLFLPSDPPLAWLLAKIWVRNSDFQLQELQFH
LLNTHLVAEVIAVATMRCLPGLHPIFKLLVPHIRYTMEINTRSRTQLISDGGIFDQVVST
GGGGHVQLLTRAVAQLTYHSLCPPDDLANRGLLRIPSALYARDALQLWEVTARYVKGMVH
LFYQSDDIVRGDPELQAWCREITEVGLCHAQDRGFPVSFQSRAQLCHFLTMCVFTCTAQH
AAINQGQLDWYGWVPNAPCTMRMPPPTSKDDVTMETVMGSLPDVQKACLQMTITWHLGRL
QPDMVPLGHHTEKYFSDPRTKAVLSQFQADLDNLEKEITARNEQLDLPYEYLKPSRIENS
ITI
NT seq 1992 nt   +upstreamnt  +downstreamnt
atgggccgctaccgcgtccgtgtggtcactggggcctggctcttctccggatccctcaac
ctagtgcgtttgtggctggttggggagcaccgggaggcgaaactggagctgcaactgcgg
ccagcgcggggcaaggaggaggagtttgacttcgacgttcccgaggacttggggccactg
cagtttgtgaaactgcacaaacagcacacagttgtggatgacgcctggttctgcaacctc
atcacagttcaggggccggggacaagtgcagaggccgtgtttccctgctaccgctgggtg
cagggagagggaatcctgagcctcccggaggggacagcccgcctggcaggagacaatgcc
ttagatgtcttccagaagtatcgagaaaaggaactgaaggaaagacaacagacctactgc
tgggccacctggaaagaaggcttacctcagacaatagcagcggactgtaaggatgacctt
cctccaaatatgagattccatgaggagaagagactggactttgaatggacgttgaaggcg
ggggttctggaaatgggcctcaaacgtgtttataccctcctgagaagctggaaccatctg
gaagactttgatcagatcttctggggccagaagagtgccttggccgagaaggttcaccag
tgttggcaggaagatgaactctttggctaccagttcctcaatggcgccaaccccatgctt
ttgagacgctccacctctctgccctccagactggtactgccctctgggatggaggagctt
caagctcagttggagaaagaactcaagaatggatccctgtttgaagctgactttatcctg
ctggatggaattccagctaatgtgatccgaggagaaccacagtacctggctgcccctctt
gtcatgctgaggatggaccccggtgggaagctgctacccatggctatccagattcagccc
cctaaccccagctccccagctccaacactgttcctgccctcggatcctccacttgcctgg
ctcttggctaagatctgggtccgaaattcagatttccaactgcaggagctccaattccat
ttgctgaacacccatctggtggctgaggtcatcgctgttgccaccatgagatgcctccca
ggactgcaccctatcttcaagctcctcgttccacacatccgttacactatggaaattaac
acgcgaagccggacccagctcatctcagatggaggaatatttgatcaggtagtgagcaca
ggtggaggcggccatgttcagttgcttactcgggcagtggctcagctgacttaccactcc
ctctgtcctcctgatgatctggctaaccgaggcctgctgagaatcccaagtgctctctat
gctcgggatgctttacagctctgggaagtcactgccaggtatgtgaaggggatggtccat
ctcttctaccagagtgatgatattgtgaggggagacccagagctgcaggcctggtgtcgg
gagatcactgaagtggggctgtgccatgcccaggacagaggattccctgtctccttccag
tcccgggctcagctctgccatttcctcaccatgtgtgttttcacatgcactgcccagcat
gctgccatcaaccagggccagctggactggtatggttgggtacctaatgctccatgcaca
atgaggatgcctccgcccaccagcaaggacgacgtgacgatggagaccgtgatggggtcg
ctacctgatgtgcagaaggcctgtcttcagatgactatcacatggcacctgggtcgcctg
cagccagacatggtacctctaggacaccacacagaaaaatatttctcagacccaaggacc
aaagctgtgctcagccaatttcaagcagatttggacaatttggagaaagagattacagcc
cggaatgagcaacttgacctgccttatgaatacctcaagcccagccgcatagagaacagt
atcaccatctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
Protein domain (2)   
   Pfam (2)   
All databases (61)   

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